Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methalthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 7/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methalthiazide SCHEMBL120865 | 0.96 | CHRM1 (0.69) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E | |
| Methalthiazide SCHEMBL29691455 | 0.96 | CHRM1 (0.69) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E | |
| Methyclothiazide SCHEMBL8065909 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E | |
| Methyclothiazide SCHEMBL8051136 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E | |
| Methyclothiazide SCHEMBL27178 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E | |
| Methyclothiazide SCHEMBL1819665 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E | |
| Methyclothiazide SCHEMBL29363642 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E | |
| Methyclothiazide SCHEMBL49396 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E | |
| Methalthiazide SCHEMBL1237868 | 0.86 | ADRA1A (0.56) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E | |
| Polythiazide SCHEMBL6929926 | 0.85 | CHRM1 (0.76) | CHRM1ADRA1ACYP2C9CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109475645-A | MicroRNA composition and its preparation and application | 先进瑞金医疗技术有限公司 | 2019-03-15 | — | — | CN | disclosed |