Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | WDR5 | P61964 | 1/20 | 0.60 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | PGR | P06401 | 2/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29561210 | 1.00 | POLB (0.71) | POLBMEN1KMT2AWDR5PFKFB3 | |
| SCHEMBL17331335 | 0.89 | POLB (0.78) | POLBMEN1KMT2AWDR5PFKFB3 | |
| SCHEMBL2825155 | 0.85 | CPT1A (0.71) | POLBMEN1KMT2AMAPT | |
| SCHEMBL2831061 | 0.85 | PFKFB3 (0.71) | POLBMEN1KMT2APFKFB3MAPT | |
| SCHEMBL29875309 | 0.85 | PFKFB3 (0.71) | POLBMEN1KMT2APFKFB3MAPT | |
| SCHEMBL29369447 | 0.85 | PFKFB3 (0.71) | POLBMEN1KMT2APFKFB3MAPT | |
| SCHEMBL29562342 | 0.84 | PGR (0.72) | MEN1KMT2AALDH1A1PGRCYP19A1 | |
| SCHEMBL29561272 | 0.83 | PGR (0.67) | MEN1KMT2AMAPTALDH1A1PGR | |
| SCHEMBL894613 | 0.83 | POLB (0.82) | POLBMEN1KMT2APFKFB3MAPT | |
| SCHEMBL29561644 | 0.82 | HSD17B2 (0.65) | MEN1KMT2AALDH1A1PGRCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384694-A | SIRT6 small molecule agonist and its application | 上海交通大学医学院 | 2019-02-26 | — | — | CN | disclosed |