Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4584445 | 0.94 | MAPT (0.55) | MAPTHTTKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL22609596 | 0.93 | MAPT (0.54) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL2718370 | 0.88 | SYK (0.53) | MAPK8MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL3718998 | 0.88 | MAPT (0.52) | MAPK8MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL3638560 | 0.84 | MAPK1 (0.50) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL21774769 | 0.83 | SYK (0.48) | MAPK8MAPK9MAPTHTTKDM4E | |
| SCHEMBL21774760 | 0.83 | MAPT (0.45) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL21774801 | 0.82 | SYK (0.46) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL28284467 | 0.81 | BTK (0.49) | MAPK8MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL21774807 | 0.81 | SYK (0.50) | MAPTHTTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061967-B | The nicotinamide compounds replaced through heteroaryl | 百时美施贵宝公司 | 2019-04-19 | — | — | CN | claimed |