Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | ATM | Q13315 | 3/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21774760 | 0.92 | MAPT (0.45) | MAPK1KCNH2ATMATRMAPT | |
| SCHEMBL30115228 | 0.92 | MAPT (0.47) | MAPK1KCNH2ATMATRMAPT | |
| SCHEMBL4584445 | 0.90 | MAPT (0.55) | KCNH2MAPTHTTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL22609596 | 0.88 | MAPT (0.54) | KCNH2MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL30260224 | 0.87 | MAPK1 (0.51) | MAPK1MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL2718370 | 0.87 | SYK (0.53) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL3718998 | 0.87 | MAPT (0.52) | KCNH2ATMATRMAPTHTT | |
| SCHEMBL28282980 | 0.84 | MAPK8 (0.52) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL28284467 | 0.80 | BTK (0.49) | KCNH2MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL28079567 | 0.80 | RPS6KB1 (0.65) | MAPK1KCNH2MAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | claimed |
| WO-2008074749-A9 | INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-05-07 | — | — | WO | claimed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | claimed |