Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 12/20 | 0.76 |
| ▸ | HPGDS | O60760 | 6/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542481 | 0.87 | HCAR3 (1.00) | HCAR3HCAR2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1656808 | 0.81 | HCAR3 (1.00) | HCAR3HCAR2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL8115278 | 0.80 | HCAR3 (0.97) | HCAR3HCAR2 | |
| SCHEMBL12277201 | 0.77 | HCAR3 (0.79) | HCAR3HCAR2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL17307583 | 0.76 | HCAR3 (0.73) | HCAR3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| Hydrochloric Acid SCHEMBL2415307 | 0.76 | HCAR3 (0.77) | HCAR3HCAR2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL15583701 | 0.75 | HCAR3 (0.54) | HCAR3HPGDS | |
| SCHEMBL15551641 | 0.75 | HCAR3 (0.54) | HCAR3HPGDS | |
| SCHEMBL15551643 | 0.75 | HCAR3 (0.54) | HCAR3HPGDS | |
| SCHEMBL15551934 | 0.75 | HCAR3 (0.54) | HCAR3HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061967-B | The nicotinamide compounds replaced through heteroaryl | 百时美施贵宝公司 | 2019-04-19 | — | — | CN | disclosed |