SCHEMBL8115278

SCHEMBL8115278

O=C(O)c1ccc(NC2CCCCC2)nc1

nearest known ligand 0.97

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 15/20 0.97
HDAC3 O15379 1/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC2 Q92769 1/20 0.51
HDAC6 Q9UBN7 1/20 0.51
F2R P25116 1/20 0.50
HCAR2 Q8TDS4 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1656808 0.98 HCAR3 (1.00) HCAR3HDAC3HDAC1HDAC2HDAC6
SCHEMBL1542481 0.92 HCAR3 (1.00) HCAR3HCAR2
SCHEMBL17276030 0.86 HCAR3 (0.72) HCAR3HDAC3HDAC1HDAC2HDAC6
SCHEMBL12277201 0.84 HCAR3 (0.79) HCAR3HCAR2
Hydrochloric Acid SCHEMBL2415307 0.83 HCAR3 (0.77) HCAR3HCAR2
SCHEMBL5233530 0.81 HCAR3 (0.66) HCAR3
SCHEMBL22247518 0.81 HCAR3 (0.70) HCAR3HDAC3HDAC1HDAC2HDAC6
SCHEMBL1578913 0.80 HCAR3 (0.64) HCAR3
SCHEMBL28282995 0.80 HCAR3 (0.76) HCAR3HCAR2
SCHEMBL5239807 0.79 HCAR3 (0.68) HCAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127390-A ANTITUMOR AGENTS INHIBITING FARNESYL-PROTEIN TRANSFERASE, FOR TREATING CANCER MERCK & CO., INC. (US) 2000-10-03 US disclosed
EP-1019391-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO. INC. (US) 2000-07-19 EP disclosed
WO-1999018096-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1999-04-15 WO disclosed