Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31191625 | 0.92 | ALOX5 (0.59) | ALOX5GAANPSR1MEN1KMT2A | |
| SCHEMBL89676 | 0.92 | ALOX5 (0.59) | ALOX5GAANPSR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27849245 | 0.90 | ALOX5 (0.57) | ALOX5GAANPSR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4195457 | 0.90 | ALOX5 (0.57) | ALOX5GAANPSR1MEN1KMT2A | |
| Phenoxazine SCHEMBL28101788 | 0.80 | ALOX5 (0.77) | ALOX5GAANPSR1MEN1KMT2A | |
| SCHEMBL3984907 | 0.76 | ALOX5 (0.57) | ALOX5GAANPSR1MEN1KMT2A | |
| SCHEMBL1867028 | 0.74 | ALOX5 (0.59) | ALOX5GAANPSR1MEN1KMT2A | |
| SCHEMBL3662427 | 0.74 | ADRB1 (0.49) | ALOX5LMNAHTR7 | |
| Phenoxazine SCHEMBL27740242 | 0.73 | ALOX5 (0.71) | ALOX5GAANPSR1MEN1KMT2A | |
| SCHEMBL17994843 | 0.73 | AHR (0.44) | ALOX5GAAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106537103-B | Ultraviolet light perception tablet, ultraviolet light perception set group and ultraviolet light cognitive method | 富士胶片株式会社 | 2019-03-01 | — | — | CN | disclosed |