Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828925 | 0.89 | GRM5 (0.49) | GRM5TNNI3KCCNT1CDK1CCNB1 | |
| SCHEMBL2829947 | 0.88 | GRM5 (0.49) | GRM5CCNT1CDK1CCNB1CCNA2 | |
| SCHEMBL2829970 | 0.88 | GRM5 (0.46) | GRM5CDK1CDK2LMNAMAPT | |
| SCHEMBL2830981 | 0.81 | GRM5 (0.50) | GRM5JAK2NPC1RAB9AL3MBTL1 | |
| SCHEMBL2830236 | 0.79 | GRM5 (0.71) | GRM5JAK2NAMPT | |
| SCHEMBL2829440 | 0.79 | GRM5 (0.51) | GRM5MAPK1 | |
| SCHEMBL2832204 | 0.78 | GRM5 (0.56) | GRM5JAK2 | |
| SCHEMBL2826336 | 0.78 | GRM5 (0.70) | GRM5SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2832138 | 0.78 | GRM5 (0.56) | GRM5SMN1; SMN2JAK2NPC1RAB9A | |
| SCHEMBL2829041 | 0.76 | GRM5 (0.54) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |