Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828925 | 0.88 | GRM5 (0.49) | GRM5SIRT2RAB9ACDK1CDK2 | |
| SCHEMBL2828459 | 0.88 | GRM5 (0.46) | GRM5SMN1; SMN2MAPTLMNATSHR | |
| SCHEMBL2829947 | 0.88 | GRM5 (0.49) | GRM5CDK1CDK2 | |
| SCHEMBL2830981 | 0.81 | GRM5 (0.50) | GRM5MEN1KMT2ARAB9APIK3CA | |
| SCHEMBL2829440 | 0.79 | GRM5 (0.51) | GRM5MAPK1 | |
| SCHEMBL2830236 | 0.79 | GRM5 (0.71) | GRM5PIK3CAPIK3CG | |
| SCHEMBL2832204 | 0.78 | GRM5 (0.56) | GRM5 | |
| SCHEMBL2826336 | 0.77 | GRM5 (0.70) | GRM5SMN1; SMN2RAB9A | |
| SCHEMBL2832138 | 0.77 | GRM5 (0.56) | GRM5SMN1; SMN2RAB9A | |
| SCHEMBL2829041 | 0.75 | GRM5 (0.54) | GRM5PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |