SCHEMBL28286221

SCHEMBL28286221

COc1ccc(CC[C@H]2Cc3cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc(O)c3C(=O)O2)cc1

nearest known ligand 0.54

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
SLC5A1 P13866 5/20 0.53
KDM1A O60341 1/20 0.51
SLCO2B1 O94956 2/20 0.49
PTPN1 P18031 2/20 0.49
SYNJ2 O15056 1/20 0.48
SLC5A2 P31639 4/20 0.47
TYR P14679 2/20 0.45
CDK5 Q00535 1/20 0.44
CDK5R1 Q15078 1/20 0.44
EPHX2 P34913 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30330184 0.81 CYP19A1 (0.50) SLC5A1SLC5A2
SCHEMBL28057641 0.81 CYP19A1 (0.50) SLC5A1SLC5A2
SCHEMBL29508355 0.74 PTPN1 (0.86) NPC1RAB9AKDM1ASLCO2B1PTPN1
SCHEMBL30696687 0.74 PTPN1 (0.86) NPC1RAB9AKDM1ASLCO2B1PTPN1
SCHEMBL8388035 0.71 TYR (0.75) NPC1RAB9ASLC5A1SLC5A2TYR
SCHEMBL15589634 0.71 TYR (0.75) NPC1RAB9ASLC5A1SLC5A2TYR
SCHEMBL16785939 0.71 TYR (0.75) NPC1RAB9ASLC5A1SLC5A2TYR
SCHEMBL17623940 0.71 TYR (0.75) NPC1RAB9ASLC5A1SLC5A2TYR
SCHEMBL18022555 0.71 TYR (0.75) NPC1RAB9ASLC5A1SLC5A2TYR
SCHEMBL15533442 0.71 TYR (0.75) NPC1RAB9ASLC5A1SLC5A2TYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109512830-A Agrimonolide -6-O- glycoside is preparing the application in anticancer drug 兰州大学第医院 2019-03-26 CN claimed
CN-109512830-A Agrimonolide -6-O- glycoside is preparing the application in anticancer drug 兰州大学第医院 2019-03-26 CN disclosed