Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28284462 | 0.85 | SIRT2 (0.54) | SIRT2NUDT1SIRT3TDP1JAK2 | |
| SCHEMBL5078983 | 0.83 | SIRT3 (0.54) | SIRT2SYKSIRT3TDP1TGFBR1 | |
| SCHEMBL479807 | 0.80 | SIRT2 (0.54) | SIRT2SIRT3TDP1JAK2JAK1 | |
| SCHEMBL3569822 | 0.77 | SIRT3 (0.61) | SIRT2MKNK1MKNK2SIRT3TDP1 | |
| SCHEMBL2714846 | 0.76 | SIRT2 (0.53) | SIRT2SIRT3TDP1JAK2JAK1 | |
| SCHEMBL2717397 | 0.74 | MAPK9 (0.51) | SIRT2SIRT3TDP1TGFBR1 | |
| SCHEMBL2717012 | 0.74 | MAPK9 (0.51) | SIRT2SIRT3TDP1 | |
| SCHEMBL22201589 | 0.74 | IRAK4 (0.54) | SIRT3TDP1POLB | |
| SCHEMBL12986577 | 0.74 | TDP1 (0.53) | NUDT1SIRT3TDP1TGFBR1POLB | |
| SCHEMBL5083064 | 0.73 | PTGS1 (0.57) | SIRT2SYKSIRT3TDP1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641906-A | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | 百时美施贵宝公司 | 2019-04-16 | — | — | CN | claimed |
| CN-109641906-A | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | 百时美施贵宝公司 | 2019-04-16 | — | — | CN | disclosed |