Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.39 |
| ▸ | HPGD | P15428 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348739 | 0.87 | LMNA (0.42) | LMNAALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL1347991 | 0.86 | LMNA (0.39) | LMNAALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL28773335 | 0.82 | HPGD (0.44) | LMNAALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL1349125 | 0.82 | CSNK2A1 (0.40) | LMNAALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL5232582 | 0.82 | LMNA (0.38) | LMNAALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL1348243 | 0.79 | CSNK2A1 (0.45) | LMNAALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL1348601 | 0.79 | KIF11 (0.42) | LMNAALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL1348900 | 0.78 | LMNA (0.39) | LMNAALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL1349129 | 0.77 | LCK (0.43) | LMNAALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL1349027 | 0.76 | LMNA (0.39) | LMNAALDH1A1HPGDKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863818-B1 | ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-03-10 | — | — | EP | claimed |