Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PANK3 | Q9H999 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826663 | 0.85 | PTPN11 (0.54) | L3MBTL1RAB9AHRH3MAPTKDM4E | |
| SCHEMBL4969527 | 0.83 | KCNQ3 (0.60) | L3MBTL1RAB9AMAPTKDM4ECYP1A2 | |
| SCHEMBL27961413 | 0.83 | KCNQ3 (0.56) | L3MBTL1RAB9AMAPTKDM4ECYP1A2 | |
| SCHEMBL2829620 | 0.83 | HRH3 (0.53) | L3MBTL1RAB9AHRH3MAPTKDM4E | |
| SCHEMBL2828179 | 0.83 | LMNA (0.54) | RAB9AHRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL2829625 | 0.82 | HRH3 (0.54) | L3MBTL1RAB9AHRH3MAPTKDM4E | |
| Cyclohexane SCHEMBL2829875 | 0.82 | RAB9A (0.52) | L3MBTL1RAB9AHRH3MAPTKDM4E | |
| Cyclohexane SCHEMBL4943993 | 0.81 | GRIN2D (0.46) | HRH3PANK3 | |
| SCHEMBL23245962 | 0.81 | HRH3 (0.46) | L3MBTL1RAB9AHRH3MAPTKDM4E | |
| SCHEMBL29618380 | 0.81 | HRH3 (0.46) | L3MBTL1RAB9AHRH3MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824829-B1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-05-05 | — | — | EP | claimed |