SCHEMBL28287652

SCHEMBL28287652

CC(C)(C)c1cc(CCC(=O)N2CNCN(C(=O)CCc3cc(C(C)(C)C)cc(C(C)(C)C)c3O)C2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.54
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
ALDH1A1 P00352 1/20 0.40
XBP1 P17861 1/20 0.40
MAPK1 P28482 1/20 0.40
HTT P42858 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
CYP2C19 P33261 3/20 0.35
NR5A2 O00482 1/20 0.35
NR5A1 Q13285 1/20 0.35
CYP2C9 P11712 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
TSHR P16473 1/20 0.34
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33
LMNA P02545 1/20 0.33
RECQL P46063 1/20 0.33
HSPA5 P11021 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8608136 0.86 GAA (0.68) GAAMEN1KMT2AALDH1A1XBP1
SCHEMBL28493854 0.82 KMT2A (0.62) GAAMEN1KMT2AALDH1A1TSHR
SCHEMBL265814 0.76 NR1H4 (0.48) GAAALDH1A1XBP1MAPK1HTT
SCHEMBL30206727 0.76 NR1H4 (0.48) GAAALDH1A1XBP1MAPK1HTT
Hydrogen Sulfide SCHEMBL28833668 0.74 NR1H4 (0.47) GAAALDH1A1XBP1MAPK1HTT
SCHEMBL27937155 0.74 GAA (0.42) GAAMEN1KMT2AALDH1A1XBP1
SCHEMBL27886338 0.74 GAA (0.43) GAAKMT2AALDH1A1XBP1MAPK1
Ethane SCHEMBL19639572 0.74 NR1H4 (0.47) GAAALDH1A1XBP1MAPK1HTT
SCHEMBL8608650 0.74 GAA (0.68) GAAMEN1KMT2AALDH1A1CYP2C19
Bicarbonate SCHEMBL27965705 0.74 NR1H4 (0.44) GAAALDH1A1XBP1MAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109666121-A A kind of hydridization dynamic crosslinking polymer and its application 翁秋梅 2019-04-23 CN disclosed
CN-109666120-A A kind of energy-absorbing method based on hydridization dynamic aggregation object 翁秋梅 2019-04-23 CN disclosed