SCHEMBL28290102

SCHEMBL28290102

O=COC(c1ccccc1)c1cc(C(F)(F)F)n[nH]1

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 4/20 0.35
TDO2 P48775 4/20 0.35
SLC6A3 Q01959 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
HPGD P15428 1/20 0.32
TACR1 P25103 2/20 0.31
KMT2A Q03164 2/20 0.31
PTGS2 P35354 1/20 0.31
ATM Q13315 1/20 0.31
FABP4 P15090 1/20 0.31
HTT P42858 1/20 0.31
PARP1 P09874 1/20 0.30
MEN1 O00255 1/20 0.30
GPR55 Q9Y2T6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28288667 0.77
SCHEMBL28058866 0.72 IDO1 (0.33) IDO1TDO2KMT2AHTTPARP1
SCHEMBL858 0.71 CYP2D6 (0.42) IDO1TDO2SLC6A3KMT2AHTT
SCHEMBL28785325 0.70 TACR1 (0.34) TACR1FABP4
SCHEMBL27934677 0.70 L3MBTL1 (0.35) IDO1TDO2TACR1HTT
SCHEMBL29006272 0.69 TACR1 (0.45) TACR1KMT2AMEN1
Hydrochloric Acid SCHEMBL10708013 0.69 HTT (0.44) IDO1TDO2SLC6A3KMT2AHTT
SCHEMBL27921924 0.68 KMT2A (0.33) SLC6A3KMT2AATMHTTMEN1
SCHEMBL27757169 0.68 IDO1 (0.39) IDO1TDO2KMT2AMEN1GPR55
SCHEMBL28330269 0.68 IDO1 (0.36) IDO1TDO2KMT2AMEN1GPR55

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109689629-A The method for preparing 3- fluoroalkyl -5- pyrazole carboxylate and 3- fluoroalkyl -5- pyrazole carboxylic acid 拜耳作物科学股份公司 2019-04-26 CN disclosed