SCHEMBL28058866

SCHEMBL28058866

O=COC(c1ccccc1)c1c[nH]nc1C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 4/20 0.33
TDO2 P48775 4/20 0.33
MAPK1 P28482 1/20 0.31
HTT P42858 1/20 0.31
PARP1 P09874 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
GPR55 Q9Y2T6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27757169 0.76 IDO1 (0.39) IDO1TDO2MEN1KMT2AGPR55
SCHEMBL27742901 0.76 SLC6A2 (0.32) PARP1
SCHEMBL28290102 0.72 IDO1 (0.35) IDO1TDO2HTTPARP1MEN1
SCHEMBL858 0.71 CYP2D6 (0.42) IDO1TDO2MAPK1HTTKMT2A
SCHEMBL27934677 0.70 L3MBTL1 (0.35) IDO1TDO2MAPK1HTT
SCHEMBL27920982 0.69 MEN1 (0.33) IDO1TDO2MEN1KMT2A
Hydrochloric Acid SCHEMBL10708013 0.69 HTT (0.44) IDO1TDO2MAPK1HTTMEN1
SCHEMBL28330269 0.68 IDO1 (0.36) IDO1TDO2MEN1KMT2AGPR55
SCHEMBL8391285 0.66 PARP1 (0.34) PARP1
Cyclopropane SCHEMBL28325005 0.66 CYP2D6 (0.38) IDO1TDO2MAPK1HTTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105461629-A Preparation method of 3-fluoroalkyl-1H-pyrazole-4-formic ester UNIV TIANJIN 2016-04-06 CN disclosed