Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.53 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28290323 | 0.84 | SPHK2 (0.50) | SPHK2SPHK1TRPV6HRH3SIGMAR1 | |
| SCHEMBL28872406 | 0.82 | SLC18A2 (0.53) | SPHK2SPHK1HRH3 | |
| SCHEMBL28291778 | 0.81 | HRH3 (0.59) | SPHK2SPHK1TRPV6HRH3 | |
| SCHEMBL28291886 | 0.81 | MAOB (0.48) | OPRK1SPHK2SPHK1TRPV6HRH3 | |
| SCHEMBL27847965 | 0.79 | HRH3 (0.74) | HRH3 | |
| SCHEMBL28290308 | 0.79 | HRH3 (0.70) | SPHK2SPHK1HRH3SIGMAR1 | |
| SCHEMBL9372378 | 0.77 | HRH3 (0.65) | SPHK2SPHK1TRPV6HRH3SIGMAR1 | |
| SCHEMBL9372386 | 0.77 | HRH3 (0.65) | SPHK2SPHK1TRPV6HRH3SIGMAR1 | |
| SCHEMBL9376275 | 0.75 | HRH3 (0.65) | SPHK2SPHK1TRPV6HRH3SIGMAR1 | |
| SCHEMBL9376281 | 0.75 | HRH3 (0.65) | SPHK2SPHK1TRPV6HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641878-A | DIPROVOCIM: a new class of effective TLR agonist | 斯克里普斯研究学院 | 2019-04-16 | — | — | CN | disclosed |