Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL28289070 | 0.86 | CHRM2 (0.38) | ALOX15CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL1087900 | 0.79 | CYP2D6 (0.46) | ALOX15CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL28135479 | 0.78 | HRH3 (0.44) | ALOX15TSHRALDH1A1CYP2C9KDM4E | |
| SCHEMBL11387438 | 0.77 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPT | |
| SCHEMBL6486975 | 0.77 | ALOX15 (0.40) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL3015928 | 0.76 | SLC6A2 (0.49) | ALOX15CYP2D6CHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL29232460 | 0.75 | USP7 (0.36) | ALDH1A1USP7 | |
| Hydrochloric Acid SCHEMBL29232267 | 0.75 | USP7 (0.36) | ALDH1A1USP7 | |
| SCHEMBL31155324 | 0.74 | USP7 (0.35) | USP7 | |
| SCHEMBL211751 | 0.73 | ALOX15 (0.72) | ALOX15CYP2D6CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-109563092-A | It can be used as the 2- phenylimidazole of the active inhibitor of mammal tyrosine kinase ROR1 simultaneously [4,5-B] pyridine -7- amine derivative | 坎塞拉有限公司 | 2019-04-02 | — | — | CN | disclosed |