Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.49 |
| ▸ | TSHR | P16473 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | PDE8B | O95263 | 3/20 | 0.39 |
| ▸ | PDE8A | O60658 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL28289208 | 0.86 | ALOX15 (0.40) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL211751 | 0.78 | ALOX15 (0.72) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL4914558 | 0.78 | ALOX15 (0.72) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL19381825 | 0.77 | LMNA (0.52) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL15084367 | 0.77 | LMNA (0.52) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL14375259 | 0.75 | ALOX15 (0.52) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL18709319 | 0.73 | ALOX15 (0.47) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL14338850 | 0.73 | ALOX15 (0.56) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL13676575 | 0.72 | ALOX15 (0.44) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL4487346 | 0.72 | ALOX15 (0.59) | ALOX15CYP2D6TSHRALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-109563092-A | It can be used as the 2- phenylimidazole of the active inhibitor of mammal tyrosine kinase ROR1 simultaneously [4,5-B] pyridine -7- amine derivative | 坎塞拉有限公司 | 2019-04-02 | — | — | CN | disclosed |