Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30603215 | 0.73 | HSD17B10 (0.39) | SMN1; SMN2CRHR1ALDH1A1NPSR1KDM4E | |
| SCHEMBL30926135 | 0.64 | SMN1; SMN2 (0.39) | SMN1; SMN2CRHR1ALDH1A1NPSR1KDM4E | |
| SCHEMBL9540875 | 0.64 | ALDH1A1 (0.42) | HRH4SMN1; SMN2ALDH1A1NPSR1KDM4E | |
| SCHEMBL14868885 | 0.64 | ALDH1A1 (0.38) | HRH4CRHBPCRHR2SMN1; SMN2NUDT1 | |
| SCHEMBL5366019 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL29629263 | 0.63 | ALDH1A1 (0.41) | HRH4SMN1; SMN2ALDH1A1NPSR1KDM4E | |
| SCHEMBL5387398 | 0.63 | SMN1; SMN2 (0.44) | HRH4CRHBPCRHR2SMN1; SMN2NUDT1 | |
| SCHEMBL1458548 | 0.63 | HRH4 (0.61) | HRH4CRHBPCRHR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL4140306 | 0.63 | HRH4 (0.61) | HRH4CRHBPCRHR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL25598202 | 0.62 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1NPSR1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109705033-B | N-heteroaryl sulfonamide derivative, preparation and application | 杭州壹瑞医药科技有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-109705033-A | N- heteroaryl sulfonamide analog derivative and preparation and application | 杭州壹瑞医药科技有限公司 | 2019-05-03 | — | — | CN | disclosed |