Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28245589 | 0.81 | TSHR (0.81) | TSHRKMT2AALDH1A1ERN1CES2 | |
| SCHEMBL3725488 | 0.80 | TSHR (0.68) | TSHRERN1CES2CES1PRSS1 | |
| SCHEMBL29018355 | 0.78 | KMT2A (0.67) | TSHRKMT2AALDH1A1HSD17B10LMNA | |
| SCHEMBL3019503 | 0.78 | HSD17B10 (0.58) | KMT2AALDH1A1CES1HSD17B10MAPT | |
| SCHEMBL894417 | 0.77 | TSHR (1.00) | TSHRKMT2AALDH1A1CES2CES1 | |
| SCHEMBL29848105 | 0.77 | TSHR (1.00) | TSHRKMT2AALDH1A1CES2CES1 | |
| SCHEMBL28012071 | 0.77 | KMT2A (0.61) | TSHRKMT2AALDH1A1HSD17B10TP53 | |
| Hydrochloric Acid SCHEMBL7389430 | 0.76 | TSHR (0.96) | TSHRKMT2AALDH1A1CES2CES1 | |
| Methane SCHEMBL28159024 | 0.76 | TSHR (0.96) | TSHRKMT2AALDH1A1CES2CES1 | |
| SCHEMBL27872956 | 0.75 | ERN1 (0.48) | TSHRALDH1A1ERN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109562137-A | Methods and compositions for treating conditions associated with abnormal inflammatory responses | 第波生物公司 | 2019-04-02 | — | — | CN | disclosed |