Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PTPRC | P08575 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | S100A4 | P26447 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | GPR3 | P46089 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733977 | 0.86 | HSD17B10 (0.58) | HSD17B10POLBRAB9APTGS2KMT2A | |
| SCHEMBL27652680 | 0.86 | HSD17B10 (0.58) | HSD17B10POLBRAB9APDE7APTGS2 | |
| SCHEMBL10405791 | 0.85 | HSD17B10 (0.72) | HSD17B10POLBPDE7AKMT2AALDH1A1 | |
| SCHEMBL28207049 | 0.83 | PTGS2 (0.73) | POLBRAB9APTGS2KMT2AALDH1A1 | |
| SCHEMBL6391559 | 0.83 | PTGS2 (0.69) | POLBRAB9APTGS2KMT2AALDH1A1 | |
| SCHEMBL10426676 | 0.83 | HSD17B10 (0.55) | HSD17B10POLBRAB9AKMT2AALDH1A1 | |
| SCHEMBL16013792 | 0.83 | HSD17B10 (0.55) | HSD17B10POLBPTGS2KMT2AALDH1A1 | |
| SCHEMBL19175213 | 0.83 | PDE7A (0.61) | HSD17B10POLBRAB9APDE7AKMT2A | |
| SCHEMBL28276250 | 0.81 | HSD17B10 (0.53) | HSD17B10POLBRAB9AKMT2AALDH1A1 | |
| SCHEMBL8382506 | 0.80 | POLB (0.64) | POLBRAB9APTGS2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105102449-A | Antiviral compounds | HOFFMANN LA ROCHE | 2015-11-25 | — | — | CN | claimed |
| CN-109652098-A | A kind of aligning agent for liquid crystal, liquid crystal orientation film and liquid crystal display element | 中节能万润股份有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-109369641-A | A kind of organic electroluminescence device compound | 韩国高智株式会社 | 2019-02-22 | — | — | CN | disclosed |
| EP-2964635-B1 | ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-05-02 | — | — | EP | disclosed |
| EP-2964635-B1 | ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-05-02 | — | — | EP | disclosed |
| US-9693997-B2 | Antiviral compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-9693997-B2 | Antiviral compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-07-04 | — | — | US | disclosed |
| CN-105102449-B | Antiviral compound | 豪夫迈·罗氏有限公司 | 2017-06-13 | — | — | CN | disclosed |
| CN-106831433-A | A kind of method for preparing nitro substituted biphenyl compound | 华南农业大学 | 2017-06-13 | — | — | CN | disclosed |
| CN-104230719-B | A kind of method preparing substituted biphenyl | HUAZHONG NORMAL UNIVERSITY (CN) | 2016-04-13 | — | — | CN | disclosed |
| CN-104230719-A | Method for preparing substituted biphenyl | UNIV HUAZHONG NORMAL | 2014-12-24 | — | — | CN | disclosed |
| CN-102388037-B | Quinazolinones as prolyl hydroxylase inhibitors | JANSSEN PHARMACEUTICA NV | 2014-12-03 | — | — | CN | disclosed |
| WO-2014135495-A1 | ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-09-12 | — | — | WO | disclosed |
| EP-2396316-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010093727-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-19 | — | — | WO | disclosed |
| US-20100204226-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-12 | — | — | US | disclosed |
| EP-0325892-B1 | PROCESS FOR THE PREPARATION OF HALOGENATED PRIMARY AMINES | CIBA-GEIGY AG (CH) | 1993-02-03 | — | — | EP | disclosed |
| EP-0473552-A1 | Process for the preparation of halogenated aromatic primary amines | CIBA-GEIGY AG (CH) | 1992-03-04 | — | — | EP | disclosed |
| US-4960936-A | Process for the preparation of halogenated aromatic primary amines | CIBA-GEIGY CORPORATION (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0325892-A2 | Process for the preparation of halogenated primary amines | CIBA-GEIGY AG (CH) | 1989-08-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204226-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | P4HA1, EGLN3, EGLN2 | HSD17B10 249/4885POLB 387/4885RAB9A 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.