SCHEMBL28291011

SCHEMBL28291011

CN(C(=O)c1ccc(C(F)(F)F)cc1)C1CCN(C(=O)O)CC1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 17/20 0.65
PDK2 Q15119 3/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28651657 0.84 USP30 (0.64) MCHR1PDK2
SCHEMBL20955964 0.83 PDK2 (0.66) MCHR1PDK2
SCHEMBL17559466 0.81 PDK2 (0.52) MCHR1PDK2
SCHEMBL4141929 0.81 TACR2 (0.62) MCHR1PDK2
SCHEMBL4141927 0.81 TACR2 (0.62) MCHR1PDK2
SCHEMBL21722935 0.81 CYP3A4 (0.47) MCHR1
SCHEMBL28292451 0.80 GPR119 (0.52) MCHR1PDK2
SCHEMBL28872513 0.80 SMO (0.54) MCHR1PDK2
SCHEMBL6120915 0.79 USP30 (0.53) MCHR1PDK2
SCHEMBL28292429 0.79 MCHR1 (0.60) MCHR1PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109734700-A SMO inhibitor of the piperidine structure containing benzoyl and preparation method thereof and purposes 中国药科大学 2019-05-10 CN disclosed