Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 4/20 | 0.66 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28291011 | 0.83 | MCHR1 (0.65) | PDK2MCHR1 | |
| SCHEMBL17559466 | 0.83 | PDK2 (0.52) | PDK2MCHR1USP30L3MBTL3 | |
| SCHEMBL28292451 | 0.82 | GPR119 (0.52) | PDK2MCHR1USP30MAPTL3MBTL3 | |
| SCHEMBL28872513 | 0.82 | SMO (0.54) | PDK2MCHR1USP30L3MBTL3 | |
| SCHEMBL6120915 | 0.81 | USP30 (0.53) | PDK2MCHR1KMT2AMEN1USP30 | |
| SCHEMBL22624599 | 0.81 | PDK2 (0.67) | PDK2MCHR1L3MBTL1 | |
| SCHEMBL19520503 | 0.80 | PDK2 (1.00) | PDK2 | |
| SCHEMBL19520501 | 0.80 | PDK2 (1.00) | PDK2 | |
| SCHEMBL17572995 | 0.78 | MCHR1 (0.54) | PDK2MCHR1USP30L3MBTL3 | |
| SCHEMBL18924426 | 0.78 | L3MBTL1 (0.59) | PDK2MCHR1L3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448850-B1 | PIPERIDINYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| US-10428024-B2 | Piperidinyl derivatives | MERCK PATENT GMBH (DE) | 2019-10-01 | — | — | US | disclosed |
| US-20190135753-A1 | PIPERIDINYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428024-B2 | Piperidinyl derivatives | PDK1, PDK2, PDK3 | PDK2 2/4885MCHR1 4622/4885L3MBTL1 1685/4885 |
| US-20190135753-A1 | PIPERIDINYL DERIVATIVES | PDK1, PDK2, PDK3 | PDK2 2/4885MCHR1 4622/4885L3MBTL1 1685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.