SCHEMBL28291132

SCHEMBL28291132

O=[N+]([O-])c1c(Cl)cc(-c2ccccc2)cc1Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.57
TSHR P16473 2/20 0.57
HPRT1 P00492 1/20 0.53
CRHBP P24387 2/20 0.52
CRHR2 Q13324 2/20 0.52
AKR1C2 P52895 1/20 0.44
AKR1C1 Q04828 1/20 0.44
HCRTR1 O43613 1/20 0.43
PKM P14618 1/20 0.43
CYP3A4 P08684 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
ESR2 Q92731 1/20 0.42
LMNA P02545 1/20 0.41
KMT2A Q03164 2/20 0.41
POLB P06746 1/20 0.41
MAPK1 P28482 1/20 0.41
PDE7A Q13946 1/20 0.40
VCAM1 P19320 1/20 0.40
OPRK1 P41145 1/20 0.40
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL746707 0.79 CYP3A4 (0.61) ALDH1A1TSHRHPRT1CRHBPCRHR2
SCHEMBL9747267 0.78 HPRT1 (0.80) ALDH1A1HPRT1CRHBPCRHR2CYP3A4
SCHEMBL9251355 0.77 TSHR (0.58) ALDH1A1TSHRHPRT1CRHBPCRHR2
SCHEMBL28493859 0.77 HPRT1 (0.50) ALDH1A1TSHRHPRT1CRHBPCRHR2
SCHEMBL11672825 0.76 CRHBP (0.67) ALDH1A1TSHRHPRT1CRHBPCRHR2
SCHEMBL15955737 0.76 PDE7A (0.55) ALDH1A1TSHRCYP3A4LMNAPDE7A
SCHEMBL11126859 0.76 ALDH1A1 (0.52) ALDH1A1TSHRTDP1LMNAKMT2A
SCHEMBL9320625 0.75 KMT2A (0.46) ALDH1A1TSHRCYP3A4TDP1KMT2A
SCHEMBL29107305 0.75 HPRT1 (0.49) ALDH1A1TSHRHPRT1CRHBPCRHR2
SCHEMBL10975392 0.74 HPRT1 (0.51) ALDH1A1TSHRHPRT1CRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109652098-A A kind of aligning agent for liquid crystal, liquid crystal orientation film and liquid crystal display element 中节能万润股份有限公司 2019-04-19 CN disclosed