Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826716 | 0.91 | GRM5 (0.50) | GRM5NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2830980 | 0.88 | GRM5 (0.48) | GRM5SMN1; SMN2KMT2ATP53MAPT | |
| SCHEMBL2831334 | 0.87 | GRM5 (0.54) | GRM5NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2828828 | 0.87 | GRM5 (0.46) | GRM5NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2826546 | 0.87 | GRM5 (0.46) | GRM5NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2826783 | 0.87 | GRM5 (0.49) | GRM5CDK2PORCNMAPTSMARCA2 | |
| SCHEMBL2826236 | 0.87 | GRM5 (0.49) | GRM5 | |
| SCHEMBL2826248 | 0.86 | SMARCA2 (0.56) | GRM5NPC1RAB9APORCNSMARCA2 | |
| SCHEMBL2829701 | 0.86 | GRM5 (0.48) | GRM5NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2831282 | 0.85 | NPC1 (0.43) | GRM5NPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |