Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828392 | 0.88 | GRM5 (0.52) | GRM5KMT2ASORT1MEN1MAPT | |
| SCHEMBL2829130 | 0.88 | GRM5 (0.51) | GRM5KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL2826236 | 0.84 | GRM5 (0.49) | GRM5LCKSYKBMX | |
| SCHEMBL2826783 | 0.84 | GRM5 (0.49) | GRM5MAPTKDRMAPK14LMNA | |
| SCHEMBL2826248 | 0.83 | SMARCA2 (0.56) | GRM5SORT1 | |
| SCHEMBL2829701 | 0.83 | GRM5 (0.48) | GRM5KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL2833178 | 0.83 | GRM5 (0.48) | GRM5SORT1SYK | |
| SCHEMBL2826714 | 0.83 | GRM5 (0.70) | GRM5MAPT | |
| SCHEMBL2832333 | 0.83 | GRM5 (0.48) | GRM5MAPTKDRLMNASYK | |
| SCHEMBL2829461 | 0.83 | GRM5 (0.48) | GRM5KMT2AMEN1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |