Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11212903 | 0.85 | HTT (0.61) | KDM4EHTTKCNN4HPGDLMNA | |
| SCHEMBL13696493 | 0.83 | HTT (0.50) | KDM4EHTTKCNN4HPGDLMNA | |
| SCHEMBL5362778 | 0.78 | HTT (0.71) | KDM4EHTTLMNAPOLBSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL23202690 | 0.77 | HTT (0.55) | KDM4EHTTKCNN4HPGDLMNA | |
| SCHEMBL28692786 | 0.76 | KMT2A (0.45) | KCNN4HPGDCES2BCHECES1 | |
| SCHEMBL3949993 | 0.75 | PKM (0.50) | KDM4EHTTHPGDLMNAPOLB | |
| SCHEMBL13506327 | 0.74 | LMNA (0.56) | KDM4ECES2BCHECES1GRM2 | |
| SCHEMBL23112144 | 0.73 | KDM4E (0.59) | KDM4EHPGDGRM2SMN1; SMN2 | |
| SCHEMBL10436878 | 0.73 | KDM4E (0.64) | KDM4EHTTHPGDLMNAPOLB | |
| SCHEMBL5251365 | 0.73 | HTT (0.54) | KDM4EHTTHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563043-A | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-04-02 | — | — | CN | disclosed |