Pyrazole

Pyrazole

SCHEMBL28291563

NS(=O)(=O)c1nccs1.c1cn[nH]c1

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC40A1 Q9NP59 1/20 0.34
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
NOS1 P29475 1/20 0.31
HSD17B10 Q99714 1/20 0.31
NAMPT P43490 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL41731 0.82
Pyrazole SCHEMBL19285783 0.77 KMT2A (0.41) ALDH1A1TSHR
Pyrimidine SCHEMBL27745739 0.76 SLC40A1 (0.37) SLC40A1ALDH1A1TSHRNOS1HSD17B10
Aminothiazole SCHEMBL28835087 0.75 ALDH1A1 (0.60) ALDH1A1TSHRNOS1HSD17B10
Imidazole SCHEMBL10754974 0.74 ALDH1A1 (0.42) SLC40A1ALDH1A1TSHRNOS1HSD17B10
Sulfamide SCHEMBL28146364 0.74 CA1 (0.32)
Pyrazole SCHEMBL27514785 0.74 CA1 (0.33)
Formic Acid SCHEMBL30845707 0.74 ALDH1A1 (0.37) SLC40A1ALDH1A1TSHRNOS1HSD17B10
Pyrazole SCHEMBL29087893 0.71 ALDH1A1 (0.44) ALDH1A1TSHRNOS1HSD17B10
Methanesulfonamide SCHEMBL3835952 0.70 CA1 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109705101-A A kind of pyrazoles triazolylsulfonamide class compound and its solvent process for thermosynthesizing and application 中南民族大学 2019-05-03 CN claimed
CN-109705101-A A kind of pyrazoles triazolylsulfonamide class compound and its solvent process for thermosynthesizing and application 中南民族大学 2019-05-03 CN disclosed
CN-109705101-A A kind of pyrazoles triazolylsulfonamide class compound and its solvent process for thermosynthesizing and application 中南民族大学 2019-05-03 CN disclosed
CN-109705101-A A kind of pyrazoles triazolylsulfonamide class compound and its solvent process for thermosynthesizing and application 中南民族大学 2019-05-03 CN disclosed