Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12014405 | 0.86 | SMN1; SMN2 (0.53) | KDM4ESMN1; SMN2USP2HSD17B10ALOX15 | |
| SCHEMBL15068058 | 0.85 | SMN1; SMN2 (0.56) | KDM4ESMN1; SMN2USP2HSD17B10ALOX15 | |
| SCHEMBL25404852 | 0.85 | SMN1; SMN2 (0.51) | KDM4ESMN1; SMN2USP2HSD17B10ALOX15 | |
| SCHEMBL717374 | 0.83 | KDM4E (0.50) | KDM4ESMN1; SMN2HSD17B10ALOX15TSHR | |
| SCHEMBL28864679 | 0.81 | SMN1; SMN2 (0.47) | KDM4ESMN1; SMN2USP2HSD17B10ALOX15 | |
| SCHEMBL24653168 | 0.80 | TSHR (0.53) | KDM4ESMN1; SMN2HSD17B10ALOX15TSHR | |
| SCHEMBL26270891 | 0.79 | HSD17B10 (0.61) | KDM4ESMN1; SMN2USP2HSD17B10ALOX15 | |
| SCHEMBL25148143 | 0.78 | SMN1; SMN2 (0.45) | KDM4ESMN1; SMN2USP2HSD17B10ALOX15 | |
| SCHEMBL16412166 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2USP2HSD17B10ALOX15TSHR | |
| SCHEMBL1127834 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2USP2CD274ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106170489-B | New Pyrazolopyrimidine derivative and its purposes as MALT1 inhibitor | 诺华股份有限公司 | 2019-05-03 | — | — | CN | disclosed |