Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 7/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 7/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28940920 | 0.81 | ACR (0.40) | P4HTMNAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL21379406 | 0.80 | NAMPT (0.48) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL21379443 | 0.80 | ANO1 (0.46) | — | |
| SCHEMBL21379445 | 0.80 | ANO1 (0.46) | — | |
| SCHEMBL22341998 | 0.79 | P4HTM (0.48) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL20929477 | 0.78 | ADORA2A (0.44) | — | |
| SCHEMBL25745885 | 0.78 | NAMPT (0.48) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL22227949 | 0.77 | P4HTM (0.55) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL12789191 | 0.77 | EGLN1 (0.52) | HDAC3HDAC1HDAC6P4HTMNPC1 | |
| SCHEMBL22341942 | 0.77 | P4HTM (0.46) | HDAC3HDAC1HDAC8HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |