Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19306076 | 0.86 | PRKCI (0.46) | PRKCISORT1SMARCA2SMARCA4SMN1; SMN2 | |
| SCHEMBL15880501 | 0.86 | PRKCI (0.62) | PRKCISORT1SMARCA2SMARCA4SMN1; SMN2 | |
| SCHEMBL3401753 | 0.84 | PRKCI (0.47) | PRKCINPC1RAB9ATYK2JAK2 | |
| SCHEMBL25331238 | 0.80 | NOS3 (0.47) | PRKCISORT1SMARCA2SMARCA4SMN1; SMN2 | |
| SCHEMBL12488028 | 0.79 | KMT2A (0.36) | PRKCISORT1SMN1; SMN2ALOX15NPC1 | |
| SCHEMBL28940889 | 0.79 | PRKCI (0.46) | PRKCISORT1SMARCA2SMARCA4KMT2A | |
| SCHEMBL1336857 | 0.79 | CCNC (0.48) | PRKCISMARCA2SMARCA4SMN1; SMN2NPC1 | |
| SCHEMBL23168284 | 0.77 | SREBF2 (0.47) | PRKCIJAK2 | |
| SCHEMBL25174663 | 0.77 | ANO1 (0.44) | PRKCISMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL28723867 | 0.76 | SMARCA2 (0.44) | PRKCISORT1SMARCA2SMARCA4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |