Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenazine-1-Carboxylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.81 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenazine-1-Carboxylic Acid SCHEMBL27752237 | 0.90 | ALDH1A1 (0.93) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| Phenazine-1-Carboxylic Acid SCHEMBL29370801 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| Phenazine-1-Carboxylic Acid SCHEMBL27884214 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| Phenazine-1-Carboxylic Acid SCHEMBL122864 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| Phenazine-1-Carboxylic Acid SCHEMBL28160016 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| Phenazine-1-Carboxylic Acid SCHEMBL28714733 | 0.88 | ALDH1A1 (0.96) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL68995 | 0.84 | ALDH1A1 (0.88) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30548734 | 0.84 | ALDH1A1 (0.88) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19971558 | 0.80 | ALDH1A1 (0.73) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2288888 | 0.78 | ALDH1A1 (0.71) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106727577-B | Purposes of the phenazine-1-carboxylic acid as medusocongestin protease inhibitors | 中国科学院海洋研究所 | 2019-05-21 | — | — | CN | disclosed |