Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.46 |
| ▸ | TET3 | O43151 | 2/20 | 0.46 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557704 | 0.82 | — | — | |
| SCHEMBL6547622 | 0.77 | SMN1; SMN2 (0.32) | SMN1; SMN2 | |
| SCHEMBL28196876 | 0.76 | GRIK1 (0.48) | — | |
| SCHEMBL3196025 | 0.76 | GRIK1 (0.48) | — | |
| SCHEMBL11219458 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL23610187 | 0.74 | — | — | |
| SCHEMBL23923580 | 0.74 | — | — | |
| SCHEMBL1506875 | 0.74 | — | — | |
| SCHEMBL28275674 | 0.74 | MMP1 (0.52) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL20836207 | 0.74 | TDP1 (0.58) | SMN1; SMN2MMP1MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641843-A | - 2 (1H) -one of 4- hydroxyl -3- sulfonyl pyridine as APJ agonist | 百时美施贵宝公司 | 2019-04-16 | — | — | CN | disclosed |