Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acotiamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acotiamide SCHEMBL27938245 | 1.00 | ACHE (0.98) | ACHELMNANPSR1HSD17B10TSHR | |
| Acotiamide SCHEMBL6968566 | 0.99 | ACHE (1.00) | ACHELMNANPSR1HSD17B10TSHR | |
| Acotiamide SCHEMBL28293346 | 0.98 | ACHE (1.00) | ACHELMNANPSR1HSD17B10TSHR | |
| Acotiamide SCHEMBL1043131 | 0.98 | ACHE (1.00) | ACHELMNANPSR1HSD17B10TSHR | |
| Acotiamide SCHEMBL30872102 | 0.98 | ACHE (1.00) | ACHELMNANPSR1HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL6973893 | 0.94 | ACHE (0.91) | ACHELMNANPSR1HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL6975742 | 0.94 | ACHE (0.91) | ACHELMNANPSR1HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL28208032 | 0.94 | ACHE (0.86) | ACHELMNANPSR1HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL27944898 | 0.93 | ACHE (0.88) | ACHELMNANPSR1HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL6963022 | 0.92 | ACHE (0.86) | ACHELMNANPSR1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119074676-A | Composition containing acotiamide hydrochloride and preparation method thereof | 北京泰德制药股份有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-110548008-B | Acotiamide solid dispersion and composition thereof | 广东东阳光药业股份有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-117398355-A | Acotiamide hydrochloride tablet and production method thereof | 南京海纳制药有限公司 | 2024-01-16 | — | — | CN | claimed |
| CN-113121466-B | Recrystallizing solvent of acotiamide hydrochloride and refining method thereof | 成都迪康药业股份有限公司 | 2023-12-15 | — | — | CN | claimed |
| CN-113640426-B | Method for determining amine residue in acotiamide hydrochloride bulk drug by gas chromatography | 宜昌人福药业有限责任公司 | 2023-07-14 | — | — | CN | claimed |
| CN-110256373-B | Preparation method of small-particle-size acotiamide hydrochloride crystal | 迪嘉药业集团股份有限公司 | 2023-02-28 | — | — | CN | claimed |
| CN-113418995-B | Detection method of related substances in acotiamide hydrochloride | 南京一诺医药科技有限公司 | 2022-09-16 | — | — | CN | claimed |
| CN-113292512-B | Acotiamide hydrochloride impurity and preparation method thereof | 南京海纳医药科技股份有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-109999003-B | Acotiamide hydrochloride orally disintegrating tablet and preparation method thereof | 湖南华纳大药厂股份有限公司 | 2022-03-25 | — | — | CN | claimed |
| CN-113979908-A | Acotiamide hydrochloride impurity and preparation method thereof | 南京海纳医药科技股份有限公司 | 2022-01-28 | — | — | CN | claimed |
| CN-116406355-B | P38 alpha mitogen-activated protein kinase inhibitors | GEN1E生命科学公司 | 2026-05-15 | — | — | CN | disclosed |
| EP-2841109-B1 | PRODRUGS OF HYDROXYL-COMPRISING DRUGS | ASCENDIS PHARMA AS (DK) | 2026-04-15 | — | — | EP | disclosed |
| EP-4681711-A1 | DYSURIA-ALLEVIATING AGENT | Zeria Pharmaceutical Co., Ltd. (JP) | 2026-01-21 | — | — | EP | disclosed |
| US-20250332125-A1 | TREATMENT OF MODERATE AND SEVERE GASTROPARESIS | EVOKE PHARMA INC (US) | 2025-10-30 | — | — | US | disclosed |
| US-12427113-B2 | Cellulose composition, tablet, and orally disintegrating tablet | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2025-09-30 | — | — | US | disclosed |
| US-20220041684-A1 | ENGINEERED PLATELETS FOR TARGETED DELIVERY OF A THERAPEUTIC AGENT | JPV01 LTD. (GB) | 2022-02-10 | — | — | US | disclosed |
| EP-3947434-A2 | ENGINEERED PLATELETS FOR TARGETED DELIVERY OF A THERAPEUTIC AGENT | JPV01 Ltd (GB) | 2022-02-09 | — | — | EP | disclosed |
| CN-113979908-A | Acotiamide hydrochloride impurity and preparation method thereof | 南京海纳医药科技股份有限公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-113979908-A | Acotiamide hydrochloride impurity and preparation method thereof | 南京海纳医药科技股份有限公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-113979908-A | Acotiamide hydrochloride impurity and preparation method thereof | 南京海纳医药科技股份有限公司 | 2022-01-28 | — | — | CN | disclosed |