Methylene Chloride

Methylene Chloride

SCHEMBL28293379

ClCCl.O=C(O)c1cccc(C(F)(F)F)n1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.61
KDM4E B2RXH2 2/20 0.53
ALOX15 P16050 1/20 0.53
TSHR P16473 1/20 0.53
ACMSD Q8TDX5 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
AHR P35869 1/20 0.47
TAS2R14 Q9NYV8 1/20 0.46
MRGPRX4 Q96LA9 3/20 0.44
DDR1 Q08345 1/20 0.42
IRAK4 Q9NWZ3 3/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
LMNA P02545 1/20 0.40
GNE Q9Y223 1/20 0.39
CBLB Q13191 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL496206 0.93 P2RX7 (0.64) P2RX7KDM4EALOX15TSHRACMSD
SCHEMBL29375278 0.93 P2RX7 (0.64) P2RX7KDM4EALOX15TSHRACMSD
SCHEMBL31126771 0.83 P2RX7 (0.61) P2RX7AHRTAS2R14DDR1IRAK4
Bromide SCHEMBL31126732 0.81 P2RX7 (0.59) P2RX7AHRTAS2R14DDR1IRAK4
SCHEMBL27737055 0.81 P2RX7 (0.68) P2RX7KDM4EALOX15TSHRACMSD
SCHEMBL13388397 0.80 P2RX7 (0.62) P2RX7KDM4EALOX15TSHRACMSD
SCHEMBL29709918 0.80 P2RX7 (0.62) P2RX7KDM4EALOX15TSHRACMSD
SCHEMBL19029854 0.79 KDM4E (0.57) P2RX7KDM4EALOX15TSHRACMSD
SCHEMBL22835203 0.79 KDM4E (0.57) P2RX7KDM4EALOX15TSHRACMSD
SCHEMBL29381032 0.79 KDM4E (0.57) P2RX7KDM4EALOX15TSHRACMSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107400256-B A kind of preparation method of uvioresistant plastic additive 深圳市精研科洁科技股份有限公司 2019-04-19 CN claimed