Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 2/20 | 0.49 |
| ▸ | CLK1 | P49759 | 7/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312359 | 0.87 | TGFBR1 (0.54) | EPHB3CLK1SCN5ATGFBR1PIK3CA | |
| SCHEMBL311920 | 0.84 | SCN5A (0.50) | EPHB3CLK1SCN5ADYRK3CCNA2 | |
| SCHEMBL15168293 | 0.75 | SMN1; SMN2 (0.44) | DYRK3CCNA2CDK2DYRK1ADYRK2 | |
| SCHEMBL12847621 | 0.74 | EIF2AK4 (0.47) | TGFBR1PIK3CA | |
| SCHEMBL15639434 | 0.74 | PIK3CA (0.45) | EPHB3CLK1TGFBR1PIK3CAMTOR | |
| SCHEMBL21033573 | 0.74 | LMNA (0.43) | — | |
| SCHEMBL15718279 | 0.73 | MKNK1 (0.53) | DYRK3CCNA2CDK2DYRK1ADYRK2 | |
| SCHEMBL1347462 | 0.73 | SCN5A (0.55) | SCN5ADYRK3CCNA2CDK2DYRK1A | |
| SCHEMBL14740273 | 0.73 | TGFBR1 (0.44) | TGFBR1 | |
| SCHEMBL15638031 | 0.72 | TGFBR1 (0.57) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934214-B1 | OXADIAZOLYL PYRAZOLO-PYRIMIDINES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-04-07 | — | — | EP | disclosed |