Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | LPL | P06858 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15759217 | 0.86 | THRB (0.43) | OPRM1OPRK1OPRL1ACACB | |
| SCHEMBL10263959 | 0.84 | MAPT (0.38) | KDM4ESMN1; SMN2HTTLPLLIPG | |
| SCHEMBL10203106 | 0.83 | APP (0.45) | KDM4EOPRM1OPRL1SIGMAR1LPL | |
| SCHEMBL15759211 | 0.78 | THRB (0.47) | SMN1; SMN2OPRM1OPRK1OPRL1 | |
| SCHEMBL28997485 | 0.76 | AXL (0.35) | BPTFADRA1BHTR1AADRA1DADRA1A | |
| SCHEMBL28997487 | 0.76 | AXL (0.35) | BPTFADRA1BHTR1AADRA1DADRA1A | |
| SCHEMBL10263957 | 0.76 | MAPT (0.42) | SMN1; SMN2HTT | |
| SCHEMBL4939123 | 0.76 | ALDH1A1 (0.56) | KDM4ESMN1; SMN2HTT | |
| SCHEMBL30635229 | 0.76 | F2RL1 (0.46) | KDM4ESMN1; SMN2ADRA1BHTTACACB | |
| SCHEMBL10203135 | 0.75 | APP (0.42) | KDM4ESMN1; SMN2OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658625-B | Indole amide compounds as inhibitors of cellular necrosis | 株式会社LG化学 | 2019-05-03 | — | — | CN | disclosed |