Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | METAP2 | P50579 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | PDE4A | P27815 | 3/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11742008 | 0.98 | CYP1A2 (0.61) | CYP1A2IDO1METAP2MEN1KMT2A | |
| SCHEMBL10353459 | 0.87 | CYP1A2 (0.74) | CYP1A2MEN1KMT2ALMNAPDE4A | |
| SCHEMBL7298232 | 0.81 | CYP1A2 (0.65) | CYP1A2MEN1KMT2ALMNAPDE4A | |
| SCHEMBL2152938 | 0.79 | CYP1A2 (0.62) | CYP1A2METAP2MEN1KMT2ALMNA | |
| SCHEMBL4048920 | 0.79 | CYP1A2 (0.62) | CYP1A2IDO1MEN1KMT2ALMNA | |
| SCHEMBL1301730 | 0.79 | CYP1A2 (0.62) | CYP1A2IDO1MEN1KMT2ALMNA | |
| SCHEMBL11628763 | 0.79 | KMT2A (0.64) | CYP1A2IDO1METAP2MEN1KMT2A | |
| SCHEMBL11374474 | 0.79 | IDO1 (0.51) | IDO1METAP2MEN1KMT2ALMNA | |
| SCHEMBL10066830 | 0.79 | CYP1A2 (0.62) | CYP1A2METAP2MEN1KMT2ALMNA | |
| SCHEMBL928226 | 0.78 | LMNA (0.67) | CYP1A2METAP2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4052395-A | AGRICULTURAL FUNGICIDAL COMPOSITIONS CONTAINING 6-(SUBSTITUTED PHENYL)-PYRIDAZINONES AND SAID PYRIDAZINONES | SANKYO COMPANY LIMITED (JA) | 1977-10-04 | — | — | US | claimed |
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |
| CN-1078444-C | Iungicidal silicon-contraining compounds, their preparation and their agrochemical and medicinal uses | SANKYO CO (JP) | 2002-01-30 | — | — | CN | disclosed |
| CN-1173281-A | Iungicidal silicon-contraining compounds, their preparation and their agrochemical and medicinal uses | SANKYO CO (JP) | 1998-02-18 | — | — | CN | disclosed |
| CN-1037102-C | Process for preparing silicon-containing fungicidal compounds | SANKYO CO (JP) | 1998-01-21 | — | — | CN | disclosed |
| EP-0537957-B1 | Fungicidal silicon-containing compounds, their preparation and their agrochemical and medicinal uses | SANKYO CO (JP) | 1997-02-12 | — | — | EP | disclosed |
| EP-0431968-B1 | Oxetane derivatives, their preparation and their use as anti-fungal or fungicidal agents | SANKYO CO (JP) | 1995-03-15 | — | — | EP | disclosed |
| CN-1027538-C | Process for preparation of oxetane derivatives | SANKYO CO (JP) | 1995-02-01 | — | — | CN | disclosed |
| EP-0072238-B1 | PYRIDAZINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN AGRICULTURAL COMPOSITIONS AND THE TREATMENT OF SEED AND PLANTS | SANKYO COMPANY LIMITED (JP) | 1985-11-06 | — | — | EP | disclosed |
| EP-0057440-B1 | AMINOPYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND FUNGICIDAL, INSECTICIDAL AND ACARICIDAL COMPOSITIONS CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1985-05-22 | — | — | EP | disclosed |
| EP-0103114-A2 | Thienopyridine derivatives, their preparation and insecticidal and acaricidal compositions containing them | SANKYO COMPANY LIMITED (JP) | 1984-03-21 | — | — | EP | disclosed |
| US-4435402-A | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY, LIMITED (JP) | 1984-03-06 | — | — | US | disclosed |
| EP-0094082-A1 | Isoxazolinone derivatives, process for their preparation and insecticidal and acaricidal compositions containing them | SANKYO COMPANY LIMITED (JP) | 1983-11-16 | — | — | EP | disclosed |
| EP-0089650-A1 | Process for producing antifungal pyridazinone derivatives and certain novel compounds produced by such a process | SANKYO COMPANY LIMITED (JP) | 1983-09-28 | — | — | EP | disclosed |
| EP-0072238-A1 | Pyridazinone derivatives, their preparation and their use in agricultural compositions and the treatment of seed and plants | SANKYO COMPANY LIMITED (JP) | 1983-02-16 | — | — | EP | disclosed |
| EP-0057440-A1 | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-08-11 | — | — | EP | disclosed |
| US-4092311-A | Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates | AMERICAN CYANAMID COMPANY (US) | 1978-05-30 | — | — | US | disclosed |
| US-4052395-A | AGRICULTURAL FUNGICIDAL COMPOSITIONS CONTAINING 6-(SUBSTITUTED PHENYL)-PYRIDAZINONES AND SAID PYRIDAZINONES | SANKYO COMPANY LIMITED (JA) | 1977-10-04 | — | — | US | disclosed |