Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 4/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1958872 | 0.81 | MAPT (0.62) | POLBMAPTKDM4EPKMGAA | |
| SCHEMBL29482111 | 0.81 | MAPT (0.62) | POLBMAPTKDM4EPKMGAA | |
| SCHEMBL30468003 | 0.79 | MAPT (0.72) | MEN1POLBKMT2AMAPTNPSR1 | |
| SCHEMBL1699958 | 0.79 | MAPT (0.72) | MEN1POLBKMT2AMAPTNPSR1 | |
| SCHEMBL19939500 | 0.79 | POLB (0.53) | MEN1POLBKMT2AMAPTNPSR1 | |
| SCHEMBL28586443 | 0.78 | POLB (0.54) | MEN1POLBKMT2AMAPTNPSR1 | |
| SCHEMBL23064564 | 0.77 | MEN1 (0.43) | MEN1POLBKMT2AMAPTNPSR1 | |
| SCHEMBL3723081 | 0.77 | SIGMAR1 (0.64) | MEN1POLBKMT2AMAPTKDM4E | |
| SCHEMBL16038620 | 0.76 | MAPT (0.75) | MEN1KMT2AMAPTCA1CA2 | |
| SCHEMBL1958532 | 0.74 | MAPT (0.65) | MEN1POLBKMT2AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641897-B | Bcl-2 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-109641897-A | Bcl-2 selective depressant and its preparation and use | 北京赛林泰医药技术有限公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-109293656-A | Bcl-2 selective depressant and its preparation and use | 北京赛林泰医药技术有限公司 | 2019-02-01 | — | — | CN | disclosed |