Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377580 | 0.91 | KDM2B (0.55) | KDM2BABCG2MAPTRAB9ANPC1 | |
| SCHEMBL4378208 | 0.90 | KDM2B (0.54) | KDM2BABCG2MAPTRAB9ANPC1 | |
| SCHEMBL2829096 | 0.85 | ALDH1A1 (0.51) | ABCG2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL2833138 | 0.81 | ALDH1A1 (0.46) | KDM2BMAPTNPC1ALDH1A1LMNA | |
| SCHEMBL2831398 | 0.80 | ALDH1A1 (0.50) | KDM2BABCG2MAPTNPC1ALDH1A1 | |
| SCHEMBL2831500 | 0.80 | KDM4E (0.50) | MAPTNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL2829775 | 0.80 | ALDH1A1 (0.54) | KDM2BABCG2MAPTRAB9ANPC1 | |
| SCHEMBL6311842 | 0.76 | MAPT (0.56) | ABCG2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL4375757 | 0.76 | ABCG2 (0.51) | ABCG2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL4380518 | 0.75 | ABCB1 (0.52) | ABCG2MAPTRAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |