Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384539 | 0.90 | PKM (0.58) | ALDH1A1USP2MAPTNPC1LMNA | |
| SCHEMBL4380675 | 0.89 | PKM (0.60) | ALDH1A1USP2MAPTNPC1LMNA | |
| SCHEMBL2829775 | 0.87 | ALDH1A1 (0.54) | ALDH1A1USP2MAPTNPC1LMNA | |
| SCHEMBL2829559 | 0.80 | KDM2B (0.55) | ALDH1A1USP2MAPTNPC1LMNA | |
| SCHEMBL4379197 | 0.78 | GAA (0.46) | ALDH1A1USP2MAPTNPC1LMNA | |
| SCHEMBL2829096 | 0.76 | ALDH1A1 (0.51) | ALDH1A1USP2MAPTNPC1LMNA | |
| SCHEMBL2831229 | 0.75 | ALDH1A1 (0.49) | ALDH1A1USP2MAPTNPC1LMNA | |
| SCHEMBL2830259 | 0.74 | NPC1 (0.60) | ALDH1A1USP2MAPTNPC1LMNA | |
| SCHEMBL2831500 | 0.73 | KDM4E (0.50) | ALDH1A1USP2MAPTNPC1LMNA | |
| SCHEMBL28966168 | 0.73 | ALDH1A1 (0.76) | ALDH1A1USP2MAPTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |