Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12256403 | 0.83 | CA1 (0.39) | CA1CA2POLBTSHRHPGD | |
| SCHEMBL2246611 | 0.78 | KDM4E (0.42) | KMT2AEPHX2ALDH1A1KDM4EMAPT | |
| SCHEMBL8713877 | 0.78 | CA12 (0.48) | POLBTSHREPHX2ALDH1A1KDM4E | |
| SCHEMBL3308588 | 0.77 | EPHX2 (0.38) | KMT2AEPHX2MEN1 | |
| Hydrochloric Acid SCHEMBL2593006 | 0.77 | KDM4E (0.41) | KMT2AEPHX2ALDH1A1KDM4EMAPT | |
| SCHEMBL16099302 | 0.76 | TSHR (0.36) | CA1CA2POLBTSHRHPGD | |
| SCHEMBL14388360 | 0.75 | KMT2A (0.43) | POLBKMT2AEPHX2ALDH1A1KDM4E | |
| SCHEMBL1517086 | 0.75 | EPHX2 (0.43) | EPHX2MAPTL3MBTL1 | |
| SCHEMBL22550134 | 0.75 | LMNA (0.41) | POLBTSHREPHX2KDM4EL3MBTL1 | |
| SCHEMBL8263009 | 0.75 | KDM4E (0.46) | POLBTSHRKMT2AEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324872-A1 | CDK2/4/6 Inhibitors | PFIZER INC. (US) | 2022-10-13 | — | — | US | disclosed |
| CN-109803968-A | Pyridopyrimidinone CDK2/4/6 inhibitor | 辉瑞公司 | 2019-05-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324872-A1 | CDK2/4/6 Inhibitors | CDK2, CDK6, CDK20 | CA1 3756/4885CA2 2490/4885POLB 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.