Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18389990 | 0.82 | LMNA (0.42) | LMNAGAAEPHX2TRPV4KDM4E | |
| SCHEMBL12205468 | 0.81 | POLB (0.50) | LMNAGAATRPV4KDM4ETSHR | |
| SCHEMBL8260696 | 0.77 | EPHX2 (0.35) | EPHX2POLBNPSR1L3MBTL1 | |
| SCHEMBL14388360 | 0.77 | KMT2A (0.43) | EPHX2KDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL18705056 | 0.76 | LMNA (0.43) | LMNAGAAEPHX2TRPV4KDM4E | |
| SCHEMBL28296145 | 0.75 | CA1 (0.42) | EPHX2KDM4ETSHRPOLBL3MBTL1 | |
| SCHEMBL23561303 | 0.74 | POLB (0.44) | LMNAGAATRPV4KDM4ETSHR | |
| SCHEMBL10218755 | 0.74 | L3MBTL1 (0.46) | LMNAGAAKDM4ETSHRMCL1 | |
| SCHEMBL8263009 | 0.73 | KDM4E (0.46) | LMNAGAAEPHX2KDM4ETSHR | |
| SCHEMBL27544991 | 0.73 | GAA (0.41) | LMNAGAAEPHX2TRPV4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020210630-A1 | TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS | C4 THERAPEUTICS, INC. (US) | 2020-10-15 | — | — | WO | disclosed |