Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28957874 | 0.83 | KDM4E (0.42) | SMN1; SMN2KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL27973695 | 0.81 | LMNA (0.46) | SMN1; SMN2KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1268508 | 0.81 | KDM4E (0.48) | ADORA2AADORA1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL29816494 | 0.81 | KDM4E (0.48) | ADORA2AADORA1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28657632 | 0.79 | KDM4E (0.47) | ADORA2AADORA1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9375509 | 0.77 | PDE4D (0.51) | ADORA2AADORA1MAPTPDE3BPDE3A | |
| SCHEMBL27830129 | 0.77 | ADORA2A (0.51) | ADORA2AADORA1ALDH1A1CYP1A2MAPT | |
| SCHEMBL29351937 | 0.77 | ADORA2A (0.50) | ADORA2AADORA1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL27966677 | 0.77 | PDK1 (0.41) | SMN1; SMN2KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL220249 | 0.77 | GRM5 (0.42) | SMN1; SMN2KDM4EALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105307655-B | Pyridazinone compound and its be used to prepare treatment tumour shape fibrosis drug application | 弗拉特利发现实验室有限责任公司 | 2019-05-03 | — | — | CN | disclosed |