Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Catechol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | RECQL | P46063 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | APEX1 | P27695 | 2/20 | 0.59 |
| ▸ | THPO | P40225 | 2/20 | 0.59 |
| ▸ | MTOR | P42345 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 2/20 | 0.59 |
| ▸ | MMP9 | P14780 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Catechol SCHEMBL60031 | 0.94 | MAPT (0.67) | MAPTKDM4EALDH1A1ALOX15LMNA | |
| Catechol SCHEMBL28370781 | 0.91 | MAPT (0.62) | MAPTKDM4EALDH1A1ALOX15LMNA | |
| Catechol SCHEMBL27512512 | 0.91 | MAPT (0.62) | MAPTKDM4EALDH1A1ALOX15LMNA | |
| Catechol SCHEMBL28146235 | 0.91 | MAPT (0.62) | MAPTKDM4EALDH1A1ALOX15LMNA | |
| Catechol SCHEMBL1229519 | 0.91 | MAPT (0.62) | MAPTKDM4EALDH1A1ALOX15LMNA | |
| Catechol SCHEMBL27989077 | 0.88 | MAPT (0.59) | MAPTKDM4EALDH1A1ALOX15LMNA | |
| Catechol SCHEMBL27739882 | 0.84 | ALDH1A1 (0.71) | MAPTKDM4EALDH1A1ALOX15LMNA | |
| Catechol SCHEMBL7608484 | 0.84 | ALDH1A1 (0.83) | MAPTKDM4EALDH1A1ALOX15LMNA | |
| Catechol SCHEMBL2279087 | 0.82 | ALDH1A1 (0.59) | MAPTKDM4EALDH1A1ALOX15LMNA | |
| Catechol SCHEMBL14876880 | 0.81 | ALDH1A1 (0.67) | MAPTKDM4EALDH1A1ALOX15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106645357-B | A kind of preparation method of crystalline nanowire bioprobe device | 南京大学 | 2019-06-28 | — | — | CN | claimed |