Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.80 |
| ▸ | OGFRL1 | Q5TC84 | 15/20 | 0.80 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lexanopadol SCHEMBL29930643 | 0.89 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Lexanopadol SCHEMBL381022 | 0.89 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Lexanopadol SCHEMBL566686 | 0.89 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Lexanopadol SCHEMBL566559 | 0.89 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL380515 | 0.88 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL681581 | 0.87 | OPRM1 (0.75) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL16153874 | 0.85 | OPRM1 (0.75) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL682578 | 0.84 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL19525879 | 0.81 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL13805851 | 0.78 | OPRM1 (0.73) | OPRM1OGFRL1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233487-A1 | Spirocyclic cyclohexane derivatives | Grünenthal GmbH (DE) | 2010-09-29 | — | — | EP | disclosed |