Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.52 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.40 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827812 | 0.93 | SMARCA2 (0.46) | GRM5SMARCA2SMARCA4PORCNSORT1 | |
| SCHEMBL2833088 | 0.87 | GRM5 (0.56) | GRM5SMARCA2SMARCA4PORCNHDAC3 | |
| SCHEMBL2833093 | 0.87 | GRM5 (0.69) | GRM5SMARCA2SMARCA4PORCNHDAC3 | |
| SCHEMBL2826248 | 0.85 | SMARCA2 (0.56) | GRM5SMARCA2SMARCA4PORCNHDAC3 | |
| SCHEMBL2826318 | 0.85 | GRM5 (0.54) | GRM5SMARCA2SMARCA4PORCNHDAC3 | |
| SCHEMBL2831334 | 0.85 | GRM5 (0.54) | GRM5SMARCA2SMARCA4PORCNHDAC3 | |
| SCHEMBL2826714 | 0.85 | GRM5 (0.70) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2826716 | 0.84 | GRM5 (0.50) | GRM5SMARCA2SMARCA4PORCNHDAC3 | |
| SCHEMBL2831342 | 0.84 | GRM5 (0.53) | GRM5SMARCA2SMARCA4PORCNNPC1 | |
| SCHEMBL2832198 | 0.84 | GRM5 (0.52) | GRM5SMARCA2SMARCA4PORCNHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |