SCHEMBL28299548

SCHEMBL28299548

Nc1ncc2ncn(Cc3ccccc3)c2n1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.63
ALDH1A1 P00352 2/20 0.53
CYP1A2 P05177 2/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
HIF1A Q16665 1/20 0.53
PHLPP2 Q6ZVD8 1/20 0.53
CYP11B1 P15538 2/20 0.51
CYP11B2 P19099 2/20 0.51
TNF P01375 1/20 0.51
ADORA2A P29274 2/20 0.51
PI4KA P42356 1/20 0.51
PI4K2B Q8TCG2 1/20 0.51
PI4K2A Q9BTU6 1/20 0.51
PI4KB Q9UBF8 1/20 0.51
ADORA1 P30542 1/20 0.50
HRH4 Q9H3N8 1/20 0.49
PNP P00491 2/20 0.49
HSP90AA1 P07900 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6946592 0.87 HDAC6 (0.62) HDAC6ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL6944465 0.86 HDAC6 (0.55) HDAC6ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL30586360 0.85 ALDH1A1 (0.51) HDAC6ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL6945092 0.85 HDAC6 (0.64) HDAC6ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL6950880 0.85 HTT (0.54) HDAC6ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL6947944 0.84 ALDH1A1 (0.56) HDAC6ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL6939917 0.84 HDAC6 (0.56) HDAC6ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL782938 0.83 YTHDC1 (0.53) HDAC6CYP11B1CYP11B2TNFADORA2A
SCHEMBL6948072 0.83 ADORA2A (0.54) HDAC6ALDH1A1ADORA2AADORA1HSP90AA1
SCHEMBL6941912 0.82 HDAC6 (0.60) HDAC6ALDH1A1CYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116693394-A Dehydrazine method and application 大连理工大学 2023-09-05 CN disclosed
CN-109846884-A With TOR kinase inhibitor for treating cancer 西格诺药品有限公司 2019-06-07 CN disclosed