Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.44 |
| ▸ | NPC1 | O15118 | 8/20 | 0.44 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | GBA1 | P04062 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829836 | 0.89 | RAB9A (0.42) | RAB9ANPC1GRM5GBA1TP53 | |
| SCHEMBL2832205 | 0.89 | RAB9A (0.41) | RAB9ANPC1GRM5GBA1TP53 | |
| SCHEMBL2827187 | 0.87 | LCK (0.45) | RAB9ANPC1GRM5GBA1JAK2 | |
| SCHEMBL2833180 | 0.86 | RAB9A (0.54) | RAB9ANPC1GRM5GBA1TP53 | |
| SCHEMBL2825977 | 0.85 | GRM5 (0.50) | RAB9ANPC1GRM5GBA1TP53 | |
| SCHEMBL2833195 | 0.85 | RAB9A (0.43) | RAB9ANPC1GRM5GBA1TP53 | |
| SCHEMBL2830797 | 0.84 | RAB9A (0.51) | RAB9ANPC1GRM5GBA1TP53 | |
| SCHEMBL2826737 | 0.84 | RAB9A (0.56) | RAB9ANPC1GRM5GBA1TP53 | |
| SCHEMBL2831443 | 0.84 | RAB9A (0.49) | RAB9ANPC1GRM5GBA1TP53 | |
| SCHEMBL2824592 | 0.83 | RAB9A (0.41) | RAB9ANPC1GRM5GBA1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |